Magnetic hyperthermia efficiency of Mn doped Fe oxides particles loaded into PLGA

Issue title: Selected papers from the International Conference Heating by Electromagnetic Sources - HES 2019

Guest editors: Paolo Di Barba, Fabrizio Dughiero, Michele Forzan and Elisabetta Sieni

Article type: Research Article

Authors: Crich, Simonetta Geninatti^a; | Ruggiero, Maria Rosaria^a | Forzan, Michele^b | Sgarbossa, Paolo^b | Sieni, Elisabetta^c

Affiliations: [a] University of Torino, Department of Molecular Biotechnology and Health Sciences, Torino, Italy | [b] University of Padova, Department of Industrial Engineering, Padova, Italy | [c] Insubria University, Department of Theoretical and Applied Sciences, Varese, Italy

Correspondence: [*] Corresponding author: Simonetta Geninatti Crich, Department of Molecular Biotechnology and Health Sciences, University of Torino, via Nizza 52, Torino, Italy. Tel.: +39 011 6706473; Fax: +39 011 6706487; E-mail: simonetta.geninatti@unito.it

Abstract: The chemical, geometric and thermal properties of nanofluid obtained dispersing the same type of nanoparticles in water, octane and buffer solution after inclusion in polylactic and glycolic acid (PLGA) were investigated by means of an experimental set-up in adiabatic conditions. The Mn-ferrite nanoparticle were obtained by thermal decomposition. The aim is to obtain some very thermally performant nanoparticles suitable to treat cancer by Magnetic Fluid Hyperthermia (MFH). The heating properties of 1 ml suspension samples of the NPs were studied applying a time varying magnetic field of 27.1 kA/m at 245 kHz, a typical frequency for MFH, using a power generator and a cylindrical inductor.

Keywords: Magnetic Fluid Hyperthermia, Polylactic and Glycolic acid (PLGA), Mn-ferrite nanoparticles

DOI: 10.3233/JAE-209112

Journal: International Journal of Applied Electromagnetics and Mechanics, vol. 63, no. S1, pp. S123-S129, 2020