Study of the effects of hydrogel coatings on brain tissue injury in simulated neural probe insertion process

Article type: Research Article

Authors: Zhang, Wenguang^a; | Tang, Jiaqi^a | Li, Zhengwei^a

Affiliations: [a] School of Mechanical Engineering, Shanghai Jiao Tong University, Shanghai, China

Correspondence: [*] Corresponding author: Wenguang Zhang, School of Mechanical Engineering, Shanghai Jiao Tong University, 800 Dong Chuan Rd., Shanghai 200240, China. Tel./Fax: +21 34204851; E-mail: zhwg@sjtu.edu.cn

Abstract: In order to reveal the effects of insertion speed with hydrogel coatings on tissue injury, comparative experiments were carried out with the naked neural probes (as the reference) and probes with PVA-H coatings based on tissue injury evaluation system. It was found that the coatings of the neural probes would cause more serious tissue injury during the insertion process. And the insertion speed could alleviate the negative effects on the tissue injury caused by implantation of neural probes.

Keywords: Neural probe, tissue injury, PVA-H coatings, insertion speed

DOI: 10.3233/JAE-171104

Journal: International Journal of Applied Electromagnetics and Mechanics, vol. 59, no. 3, pp. 1073-1079, 2019