Temperature field distribution optimization of MFH for cancer therapy

Issue title: Proceedings from the 16th International Symposium on Applied Electromagnetics and Mechanics (ISEM 2013)

Guest editors: Xavier Maldague and Toshiyuki Takagi

Article type: Research Article

Authors: Hu, Guanzhong^a | Li, Yuling^{a; *} | Yang, Shiyou^a | Chu, Jianglong^a | Bai, Yanan^a | Huang, Jin^a

Affiliations: [a] College of EE, Zhejiang University, Hangzhou, Zhejiang, China | Université Laval, Canada | Tohoku University, Japan

Correspondence: [*] Corresponding author: Yuling Li, College of EE, Zhejiang University, Hangzhou 310027, Zhejiang, China. Tel.: +86 571 8795 1625; E-mail: liyl@zju.edu.cn

Abstract: The magnetic nanoparticles in AC alternating magnetic fields will produce a large amount of heats due to the Néer relaxation. Magnetic Fluid Hyperthermia (MFH), based on this mechanism, offers a new breakthrough and has a promising potential in tumor treatments. The temperature field distribution in the treatment and neighbor regions has a significant effect on the therapeutic result. Therefore, it is essential to control the temperature in the treatment region in a proper range (42°C∼90°C) while to guarantee a sharp gradient in the boundary of the treatment and normal regions. This study provides an automatic shape design methodology using the Finite Element Analysis (FEA) of the electromagnetic-temperature Coupled Field (CF) and a multi-objective Particle Swarm Optimization (MOPSO), to realize sufficient uniformities in the temperature field distribution while to ensure the enough temperature gradient in the cancer boundary.

Keywords: Magnetic fluid hyperthermia, magnetic nanoparticles, optimization

DOI: 10.3233/JAE-141895

Journal: International Journal of Applied Electromagnetics and Mechanics, vol. 45, no. 1-4, pp. 697-702, 2014