Affiliations: [a] School of Mechanical Engineering and Automation,
Northeastern University, Shenyang, Liaoning, China | [b] School of Resource and Civil Engineering, Northeastern
University, Shenyang, Liaoning, China | [c] Department of Mechanical Engineering, Concordia
University, Montreal, QC, Canada | Doshisha University, Kyoto, Japan | Department of Human and Information Systems, Faculty
of Engineering, Gifu University, Gifu, Japan
Correspondence:
[*]
Corresponding author: Lina Hao, School of Mechanical Engineering
and Automation Northeastern University, Shenyang 110819, Liaoning, China. Tel.:
+86 024 8368 3010; E-mail: haolina@me.neu.edu.cn
Abstract: Cell injection procedure is very essential in the field of molecular
biology, and the injection force affects the success rates very much. However,
conventional methods of manipulating individual biological cell failed to make
use of the injection force information. This article is intended to design a
static micro-force sensor with a simple structure which employs the
piezoelectric material PVDF (polyvinylidene fluoride) film as its sensing
element to detect the micro-force during cells injection and to develop a
close-loop control method to regulate the whole fore-tracking system. A
Fuzzy-PID and an ordinary PD feedback control method are employed separately in
this article to regulate the micro-force tracking system which is used to carry
out automatic living-cell injection tests. Experimental results with different
control methods are achieved. And the Fuzzy-PID and PVDF sensor based force
control method is validated.
Keywords: PVDF, force sensor, Fuzzy-PID, cell injection, inverse model
