Optimization-Based Evaluation of Concentrations in Modeling the Biosensor-Aided Measurement

Article type: Research Article

Authors: Žilinskas, Antanas | Baronas, Darius

Affiliations: Vilnius University, Faculty of Mathematics and Informatics, Naugarduko 24, LT-03225 Vilnius, Lithuania, e-mail: antanas.zilinskas@mii.vu.lt | Vilnius University, Institute of Mathematics and Informatics, Akademijos 4, LT-08663 Vilnius, Lithuania, e-mail: darius.baronas@mif.vu.lt

Abstract: The concentration of a substrate in a solution can be measured using amperometric signals of biosensors: in fact the maximum (steady state) current is measured which is calibrated in the units of concentration. Such a simple method is not applicable in the case of several substrates. In the present paper, the problem of evaluation of concentrations of several substrates is tackled by minimizing the discrepancy between the observed and modeled transition processes of the amperometric signal.

Keywords: optimization, modeling, biosensor, concentration measurement

Journal: Informatica, vol. 22, no. 4, pp. 589-600, 2011