Affiliations: Singapore Immunology Network (SIgN), Biomedical
Sciences Institutes, Agency for Science, Technology and Research (A*STAR), 8A
Biomedical Grove, Immunos #04, Singapore 138648 | Bioinformatics Institute, Agency for Science,
Technology and Research (A*STAR), 30 Biopolis Street, #07-01 Matrix,
Singapore 138671
Abstract: The innate immune system is fundamental to the recognition of
pathogens, triggering of immune-inflammatory response and host defense. Recent
advance in this area has resulted in enormous amount of data, which are stored
across different databases. Integrating relevant information from these
different data sources is difficult because of their heterogeneous nature and
dispersed physical location. We present here a single portal system, Cell
Interaction Knowledgebase, with focus on the innate immunity. In particular,
the knowledgebase houses comprehensive information on innate immune cells
and cytokines/chemokines which are the principal mediators of
communication among the immune cells. Currently the knowledgebase consists of
extensive information on 2 major innate immune cell types (Macrophages and
Dendritic cells) and 7 6 cytokines/chemokines for both human and mouse.
In addition, intra-cellular molecular interactions and inter-cellular
interactions involved in the innate immunity are curated and presented in an
interactive and dynamic manner by animated pathways and query-driven
cell-interaction map respectively. This is one of the first databases that
houses extensive phenotypic, signaling, genomic, proteomic and knockout data on
both the innate immune cells and their attendant
cytokines/chemokines, and is aimed to evolve as a one-stop-shop for
immunologists. The first version of database is available at
http://cell-interaction.bii.a-star.edu.sg/.
