Alternatively Spliced Human Genes by Exon Skipping – A Database (ASHESdb)

Article type: Research Article

Authors: Sakharkar, Meena Kishore | Perumal, Bagavathi S. | Lim, Yun Ping | Chern, Lee Pern | Yu, Yiting | Kangueane, Pandjassarame

Affiliations: Nanyang Centre for Supercomputing and Visualization, Nanyang Technological University, Singapore 639798 | BioInformatics Institute, Matrix, 30 BioPolis Street, Singapore

Note: [] Corresponding author. Tel.: +65 6790 5836; Fax: +65 6791 1859; E-mail: mmeena@ntu.edu.sg

Abstract: Alternative splicing of mRNA allows many gene products with different functions to be produced from a single coding sequence. Exon skipping is the most commonly known alternative splicing mechanism. A comprehensive database of alternative splicing by exon skipping is made available for the human genome data. 1,229 human genes are identified to exhibit alternative splicing by exon skipping.

Keywords: alternative splicing, eukaryotic gene structure, exon skipping, multiple splice variants, protein isoforms, protein diversity, skipping patterns, genome wide splicing, full length cDNA sequences, tissue specificity, computational analysis, database

Journal: In Silico Biology, vol. 5, no. 3, pp. 221-225, 2005