The Death Factors: A Combinatorial Analysis

Article type: Research Article

Authors: Bergeron, Anne | Geanta, Paul | Bergeron, Dominique

Affiliations: LACIM, Université du Québec à Montréal, C.P. 8888 Succ. Centre-Ville, Montréal, Québec, Canada, H3C 3P8, e-mail: anne@lacim.uqam.ca | Département de microbiologie et immunologie, Université de Montréal C.P. 6128 Centre-Ville, Montréal, Canada, H3C 3J7, e-mail: bergerdo@ere.umontreal.ca

Abstract: This paper presents theoretical and computational tools to understand how a small group of proteins, the death factors, are involved in widely different behavior of the cell. Experiments were done using a virtual laboratory that can simulate cellular response to different external stimuli. WARNING: It is not certain which of the theoretical protein clusters described here really occur in nature. In addition, the rules of cluster assembly are combinatorial, and thus an oversimplification to describe the real situation.

Keywords: regulatory proteins, death factors, virtual experiments, signalization pathway

Journal: In Silico Biology, vol. 1, no. 3, pp. 147-158, 1999