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Article type: Research Article
Authors: Daifuku, Richarda | Panacek, Edward A.b | Haenftling, Katherinea; | Swenson, Wendy K.a | Prescott, Amanda W.b | Johnson, John L.b
Affiliations: [a] Cetus Corporation, Emeryville, CA, USA | [b] Case Western Reserve University, University Hospitals of Cleveland, Cleveland, OH, USA
Note: [] Address reprint requests to Katherine Haenftling, Chiron, 1400 Fifty-third St., Emeryville, CA 94608, USA.
Abstract: MAB-T88 is a human monoclonal IgM antibody directed at the lipopolysaccharide of gram-negative bacteria. A protocol was designed to identify a group of septic patients with a very high likelihood of gram-negative bacteremia. All 6 patients entered in the protocol had a gram-negative source, and 4 of 6 had gram-negative bacteremia. In this patient population, MAB-T88 was shown to be safe with an effective half-life of 19.1 hours.
Keywords: gram-negative, IgM, lipopolysaccharide, monoclonal antibody, sepsis
DOI: 10.3233/HAB-1993-4107
Journal: Human Antibodies, vol. 4, no. 1, pp. 36-39, 1993
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