MTT assay dataset of polyethylenimine coated graphenoxide nanosheets on breast cancer cell lines (MCF7, MDA-MB-231, MDA-MB-468)

Article type: Research Article

Authors: Maleki, Parichehr^a | Sadeghi, Zahra^a | Shahryar Rahpeyma, Sayyed^a | Taheri, Mohammad^b | Raheb, Jamshid^{a; *}

Affiliations: [a] National Institute of Genetic Engineering and Biotechnology, Tehran, Iran | [b] Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Correspondence: [*] Corresponding author: Jamshid Raheb, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran. E-mail: Jam@nigeb.ac.ir.

Abstract: Graphen oxide has emerged as a promising tool in medical biotechnology due to its outstanding properties applicable in several fields as well as cell imaging, drug and gene delivery. Monolayer structure and high surface area of Graphen benefits elevated loading capacity of drugs rather than other nanomaterials. However Graphen oxide in physiological solutions has unfavourable reactions which confine it’s application in biomedical field without additional surface functionalization. Coating of graphenoxide by polyethylenimine is an approach to enhance biocompatibility of graphen oxide and also provides desirable physicochemical features for oligonucleotides delivery. The data presented here is related to graphenoxide-PEI characterisation and it’s cytotoxicity assay on variouse breast cancer cell lines including MDA-MB-468 and MDA-MB-231 and MCF7 by MTT assay.

Keywords: Graphen oxide, PEI, MTT assay, MDA-MB-468, MDA-MB-231, MCF7

DOI: 10.3233/HAB-200407

Journal: Human Antibodies, vol. 28, no. 3, pp. 197-202, 2020