Searching for just a few words should be enough to get started. If you need to make more complex queries, use the tips below to guide you.
Article type: Research Article
Authors: Urra, J.M.a; * | Arteta, M.b | Gómez-Caturla, A.c | García-Dur´n, F.c
Affiliations: [a] Service of Immunology, Complejo Hospitalario de Ciudad Real, Spain | [b] Service of Pharmacy, Hospital Santa Bárbara Puertollano, Spain | [c] Service of Gastroenterology, Hospital Santa Bárbara Puertollano, Spain
Correspondence: [*] Corresponding author: José Miguel Urra Ardanaz, Inmunología-Laboratorio, Hospital Alarcos, Avenida Pio XII s/n, 13002, Ciudad Real, Spain. Tel.: +34 926 213444; Fax: +34 926 212290; E-mail: jurra@hnsa.insalud.es.
Abstract: Tumor necrosis factor alpha (TNFα) has been described as a citokine involved in gastrointestinal mucosal inflammation in Crohn's disease. A single infusion of the chimeric mouse/human monoclonal antibody cA2 anti-TNFα has been established as a new therapeutical procedure. The aim of these study was to determine the effect of the monoclonal antibody cA2 on lymphocyte and monocyte TNFα-producing cells. Initially the patient, with severe Crohn's disease (Crohn's disease activity index CDAI > 350), presented a higher number of peripheral blood TNFα-producing cells than healthy controls. The patient received two cA2 treatments throughout one year due the severe activity of the disease. Before treatment the patient had a large number of TNFα producer cells. A dramatic reduction in lymphocyte and monocyte TNFα producing cells, together a clinical remission (CDAI < 150), was shown after the treatments. Four months after the first cA2 treatment, the patient had a clinical response associated with an important increment of TNFα-producing cells that extended increasing until the second cA2 treatment was averaged. These results suggest that the clinical activity of the Crohn's disease correlates with peripheral TNFα-expressing cells. The cA2 antibody, as well as of neutralize soluble TNFα, also removes TNFα-producer cells, which may collaborate with the anti-TNFαactivity of the antibody treatment.
DOI: 10.3233/HAB-2001-10206
Journal: Human Antibodies, vol. 10, no. 2, pp. 91-94, 2001
IOS Press, Inc.
6751 Tepper Drive
Clifton, VA 20124
USA
Tel: +1 703 830 6300
Fax: +1 703 830 2300
sales@iospress.com
For editorial issues, like the status of your submitted paper or proposals, write to editorial@iospress.nl
IOS Press
Nieuwe Hemweg 6B
1013 BG Amsterdam
The Netherlands
Tel: +31 20 688 3355
Fax: +31 20 687 0091
info@iospress.nl
For editorial issues, permissions, book requests, submissions and proceedings, contact the Amsterdam office info@iospress.nl
Inspirees International (China Office)
Ciyunsi Beili 207(CapitaLand), Bld 1, 7-901
100025, Beijing
China
Free service line: 400 661 8717
Fax: +86 10 8446 7947
china@iospress.cn
For editorial issues, like the status of your submitted paper or proposals, write to editorial@iospress.nl
如果您在出版方面需要帮助或有任何建, 件至: editorial@iospress.nl