Human monoclonal antibodies to MN-24 peptide of gp 120 HIV-1

Article type: Research Article

Authors: Sidorova, Ekaterina

Affiliations: Institute for Viral Preparations of Russian Academy of Medical Sciences, 1st Dubrovskaya str. 15, 109088 Moscow, Russia

Abstract: Human monoclonal IgM antibodies to synthetic peptide MN-24 corresponding to 303–325 residues of gp 120 HIV were obtained. Antibodies are made synthetic by CD5+B lymphocytes and are polyspecific: they react not only with different short peptides but with some macromolecular antigens as well. Anti-MN-24 antibodies possess antigen-binding activity but do not possess virus neutralizing activity. It is suggested that anti-MN-24 antibodies belong to the natural antibodies.

Keywords: human monoclonal antibody, viral peptides, B cells, natural antibodies

DOI: 10.3233/HAB-1999-9204

Journal: Human Antibodies, vol. 9, no. 2, pp. 107-110, 1999