Affiliations: Institute of Pathological Anatomy and Histopathology, University
of Ancona, Ancona, Italy
Note: [] Address for correspondence: Prof. Rodolfo Montironi, MD, FRCPath
Institute of Pathological Anatomy and Histopathology University of Ancona
School of Medicine Ospedale Regionale I-60020 Torrette, Ancona Italy Fax No:
+39071889985; E-mail: r.montironi@popcsi.unian.it
Abstract: High-grade prostatic intraepithelial neoplasia (PIN) is the most
likely precursor of prostatic carcinoma. PIN has a high predictive value as a
marker for carcinoma, and its identification in biopsy specimens warrants
repeat biopsy for concurrent or subsequent carcinoma. The only methods of
detection are biopsy and transurethral resection; PIN does not significantly
elevate serum PSA concentration or its derivatives, does not induce a palpable
mass, and cannot be detected by ultrasound. Androgen deprivation therapy
decreases the prevalence and extent of PIN, suggesting that this form of
treatment may play a role in chemoprevention. Radiation therapy is also
associated with a decreased incidence of PIN.
