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Serum cytokines correlated with the disease severity of generalized pustular psoriasis

Article type: Research Article

Authors: Yamamoto, Masaaki | Imai, Yasutomo | Sakaguchi, Yoshiko | Haneda, Takashi | Yamanishi, Kiyofumi

Affiliations: Department of Dermatology, Hyogo College of Medicine, Hyogo, Japan

Note: [] Corresponding author: Kiyofumi Yamanishi, Department of Dermatology, Hyogo College of Medicine, 1-1, Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan. Tel.: +81 798 45 6653; Fax: +81 798 45 6651, E-mail: kyamanis@hyo-med.ac.jp

Keywords: Generalized pustular psoriasis, cytokine, chemokine, serum, biomarker, severity of illness index

DOI: 10.3233/DMA-120958

Journal: Disease Markers, vol. 34, no. 3, pp. 153-161, 2013

Received 28 December 2012
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Accepted 28 December 2012
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Published: 2013
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Abstract

To characterize serum biomarkers reflecting the severity of generalized pustular psoriasis (GPP), we measured multiple cytokine/chemokine levels in 39 serum samples from 6 cases with GPP during the course of the disease. Serum levels of IL-4, IL-8, CXCL1 and CCL3 were positively correlated with the severity scores of GPP, white blood cell counts and serum C-reactive protein levels. Serum levels of IL-1β, IL-1ra, IL-6, IL-10, IL-12p70, IL-18, IL-22, IFN-γ and VEGF showed strong positive correlations (r> 0.4, p< 0.01) with all those 3 clinical markers. Of those, IL-10 and IL-22 were significantly decreased after treatment in parallel with the GPP score and therefore those two serum cytokines might be useful to evaluate the efficacy of treatment for GPP.

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