Affiliations: Department of Cardiology, Jagiellonian University
Medical College, Krakow, Poland | Department of Radiology, Jagiellonian University
Medical College, Krakow, Poland | Department of Interventional Cardiology, Jagiellonian
University Medical College, Krakow, Poland
Note: [] Corresponding author: Dariusz Dudek, Department of
Interventional Cardiology, Jagiellonian University Medical College, 17
Kopernika St., 31-501 Krakow, Poland. Tel.: +48 12 424 71 81; Fax: +48 12 424
71 84; E-mail: mcdudek@cyfronet.pl
Abstract: PURPOSE: The aim of the study was to evaluate the utility of
N-terminal pro-B-type natriuretic peptide (NT-pro BNP, pg/ml) assessment to
predict infarct size and left ventricle function after ST-segment elevation
myocardial infarction (STEMI) at long-term follow-up. METHODS: In 45 patients with first STEMI less than 3 hours from
symptom onset treated with mechanical reperfusion NT-pro BNP was assessed early
(at admission) and at 6 months. Cardiac magnetic resonance (CMR) parameters
(delayed enhancement infarct size (IS, %), left ventricular end-diastolic
(LVEDVI, ml/m2) and end-systolic (LVESVI, ml/m2) volume indexes) were assessed
at 6 months. RESULTS: No significant correlation was found between baseline
NT-pro BNP assessment and IS and left ventricle function after 6 months. There
was a significant correlation between 6-month NT-pro BNP and IS (r=0.65, p<
0.001) and left ventricle remodeling at 6 months (LVEDVI, r=0.53, p=0.001;
LVESVI, r=0.51, p=0.002). CONCLUSIONS: Assessment of NT-pro BNP level 6 months after STEMI
remains a good indicator of infarct size and left ventricle function at
long-term follow-up.
