Affiliations: Institute of Molecular Biomedicine, Comenius
University, Bratislava, Slovakia | Private Stomatological Praxis, Krupina, Slovakia | Department of Molecular Biology, Comenius University,
Bratislava, Slovakia | Institute of Pathophysiology, Comenius University,
Bratislava, Slovakia
Note: [] Corresponding author: Peter Celec, Institute of Molecular Biomedicine, Comenius University, Sasinkova 4, 811
08 Bratislava, Slovakia. Tel.: +421 259357296; Fax: +421 259357631; E-mail:
petercelec@gmail.com
Abstract: Background: Previous studies have shown that salivary thiobarbituric
acid reactive substances are related to the periodontal status in adults. Such
an analysis has not been done on children yet. The aim of our study was to
analyze salivary markers of oxidative stress in relation to periodontal and
dental status in children. Methods: The periodontal and dental status of 82 consecutive
pediatric dental patients was assessed. The oral hygiene index (OHI), the
papillary bleeding index (PBI) and the caries index (CI) were assessed as
clinical parameters. Markers of oxidative stress and antioxidant status were
measured in whole saliva samples. Results: Multivariate analysis of covariance showed that the
variability of PBI explains 10.9% of the variance of salivary thiobarbituric
acid reacting substances (TBARS). Advanced oxidation protein products (AOPP)
were related to CI (eta 8.6%). Measures of antioxidant status (total
antioxidant capacity and ferric reducing ability of saliva) were partially
determined by OHI (13.6% and 7.2%) and PBI (16.9% and 7.9%). Conclusions: Antioxidant status in saliva is related to oral hygiene
and periodontal status. Salivary TBARS are a potential sensitive marker of
periodontitis in children, similarly to adults, at least on a population level.
Salivary AOPP are related to caries. Potential diagnostic value of the analyzed
markers should be analyzed in further interventional studies.
