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Article type: Research Article
Authors: Ferchichi, Imen | Kourda, Nadia | Sassi, Samia | Romdhane, Khaled Ben | Balatgi, Sarra | Cremet, Jean Yves | Prigent, Claude | Elgaaied, Amel Benammar
Affiliations: Department of Biology, Laboratory of Genetics, Immunology and Human Pathology, Faculty of Sciences of Tunis, Tunis, Tunisia | Department of Histopathology, Charles Nicolle Hospital, Tunis, Tunisia | Department of Histopathology, The Oncology Institute of Saleh Azaïez, Bab Saadoun, Tunis, Tunisia | The Institute of Genetics and Development of Rennes, Rennes Cedex, France
Note: [] Corresponding author: Imen Ferchichi, Department of Biology, Laboratory of Genetics, Immunology and Human Pathology, Faculty of Sciences of Tunis, Tunis 1060, Tunisia. Tel.: +216 28 100 848; Fax: +216 71 231 401; E-mail: science.biologique@yahoo.fr
Abstract: We investigate the expression and localization of the tumor suppressor protein pVHL as well as the oncoprotein Aurora A kinase in kidney cancer. Both Aurora A kinase and pVHL protein status were evaluated using immunohistochemistry. The Aurora A expression is correlated with the Fuhrman grade and the TNM stage, while the pVHL expression is correlated with the capsule rupture and the TNM stage. Aurora A kinase expression increases in malignant tissue comparing to the non-malignant one. And there is a decrease in pVHL expression from the adjacent healthy tissues to the tumor`s ones. The two kinds of opposite tumor profiles display significant distribution difference according to TNM stages. It could be proposed that the absence of Aurora A protein associated with a strong expression of pVHL in clear cells kidney carcinoma are of good prognosis for the disease.
Keywords: pVHL, Aurora A, kidney cancer, immunohistochemistry
DOI: 10.3233/DMA-2012-00942
Journal: Disease Markers, vol. 33, no. 6, pp. 333-340, 2012
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