Article type: Research Article
Authors: Huang, Huiling | Ma, R. | Liu, Dan | Liu, Chen | Ma, Yuedong | Mai, Weiyi | Dong, Yugang;
Affiliations: Department of Cardiology, First Affiliated Hospital of
Sun Yat-Sen University, Guangzhou, Guangdong, China | Jiangsu Jiankang Vocational College, Nanjing, Jiangxi,
China | Key Laboratory on Assisted Circulation, Ministry of
Health, Guangzhou, Guangdong, China
Note: [] Corresponding author: Yugang Dong, Department of Cardiology, First Affiliated Hospital of Sun Yat-Sen University,
Guangzhou 510080, Guangdong, China. Tel.: +86 20 87755766 ext 8151; Fax: +86 20
87755766 ext 8756; E-mail: hhl127@yahoo.com.cn; Weiyi Mai, Department of
Cardiology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou
510080, Guangdong, China. Tel.: +86 20 87755766 ext 8151; Fax: +86 20 87755766
ext 8756; E-mail: wymai@hotmail.com
Abstract: Objective: The purpose of the present study was to investigate the
value of ox-LDL and oxidation ratio of LDL (ox-LDL/TC, ox-LDL/HDL-C and
ox-LDL/LDL-C) in diagnosis and prognosis evaluation in CAD patients. Also, we
aimed to observe the effect of statins on reducing level of ox-LDL and
oxidation ratio of LDL, and explore whether statins still have similar effect
on ox-LDL in a short period of therapy (within 2 weeks). Methods: Blood ox-LDL, TC, HDL-C, LDL-C, and TG were measured in
cases with acute myocardial infarction (AMI, n=177), unstable angina pectoris
(UAP, n=195), stable angina pectoris (SAP, n=228), normal control (n=120), and
high risk control (n=140). Results: Mean value of ox-LDL and oxidation ratio of LDL was
significantly higher in the CAD group than in the two control groups. The AUC
of ROC curve of ox-LDL, ox-LDL/TC, ox-LDL/HDL-C, ox-LDL/LDL-C and apoA1/apoB
were more than 0.50 (P < 0.001). Multivariate logistic regression analysis
showed that age and ox-LDL/LDL-C related with short-term, while ox-LDL/LDL-C
and ox-LDL/TC related with long-term prognosis (p < 0.05). Furthermore,
after treatment with statins for 2 weeks, TC, LDL-C, ox-LDL, ox-LDL/TC,
ox-LDL/HDL-C and ox-LDL/LDL-C decreased by 22%, 28%, 38%, 29%, 23% and 25%
respectively. And the reduction of ox-LDL by statins is independent of lowering
of LDL-C and TC. Conclusions: Ox-LDL and oxidation ratio of LDL are closely related
with AS, and they are better biomarkers for discriminating between patients
with coronary artery disease and healthy subjects. In addition, statins can
decrease level of ox-LDL significantly, which is independent of lowering of
LDL-C and TC.
Keywords: Coronary artery disease, oxidized low density lipoprotein, diagnosis, prognosis
DOI: 10.3233/DMA-2012-00941
Journal: Disease Markers, vol. 33, no. 6, pp. 295-302, 2012
Received 22 October 2012
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Accepted 22 October 2012
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Published: 2012
