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Article type: Research Article
Authors: Khojasteh-Fard, Maryam; | Abolhalaj, Milad | Amiri, Parvin | Zaki, Majid | Taheri, Zahra | Qorbani, Mostafa | Bazzaz, Javad Tavakkoly | Amoli, Mahsa M.
Affiliations: Endocrinology and Metabolism Research Center, Tehran University of Medical Sciences, Tehran, Iran | Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran | Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
Note: [] Corresponding authors: Mahsa M. Amoli, Dr Shariati Hospital, North Karegar St., Tehran 14114, Iran. Tel.: +98 21 88220037-8; Fax: +98 21 88220052; E-mail: amolimm@tums. ac.ir. and Javad Tavakkoly Bazzaz, Department of Medical Genetics, Tehran University of Medical Sciences, Poursina St., Tehran, 14176, Iran. Tel./Fax: +98 21 88953005; E-mail: tavakkolybazzazj@tums.ac.ir
Abstract: Objective: Both adaptive and innate immune systems are involved in coronary artery disease (CAD). The aim of this study was to evaluate TH17 cytokines expression profiles in un-stimulated peripheral blood lymphocytes (PBMCs) of patients with coronary artery disease. Methods: Expression profiles of IL-17, IL-23, and TGF-β1 were determined in individuals with and without CAD using Real-time PCR. Results: A significant decrease in IL-23 gene expression in un-stimulated PBMCs of patients with CAD compared to those without CAD was found (p=0.003, OR=0.045, 95% CI: 0.006–0.355). Conclusion: Our data reinforce the potential role of the IL-23 as a critical regulatory molecule that bridges the innate and adaptive arms of the immune system in the complex mechanisms associated with the development of atherosclerosis.
Keywords: Cytokine, gene, expression, CAD, IL-23
DOI: 10.3233/DMA-2012-00933
Journal: Disease Markers, vol. 33, no. 6, pp. 289-293, 2012
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