Association of progranulin and high sensitivity CRP
concentrations in gingival crevicular fluid and serum in chronic periodontitis
subjects with and without obesity
Affiliations: Department of Periodontics, Government Dental College
and Research Institute, Bangalore, Karnataka, India
Note: [] Corresponding author: AR Pradeep, Department of Periodontics,
Government Dental College and Research Institute, Bangalore-560002, Karnataka,
India. Fax: +918 26703176; E-mail: periodonticsgdcri@gmail.com
Abstract: Background: Obesity is considered as a strong risk factor of
inflammatory periodontal tissue destruction. The purpose of this study is to
determine presence of progranulin (PGRN) and high sensitivity C reactive
protein (hs CRP) levels in serum and gingival crevicular fluid (GCF) in obese
subjects with chronic periodontitis and to find an association, if any. Material and methods: 40 subjects (20 males and 20 females) were
selected based on their clinical parameters into four groups (10 subjects in
each group): group 1 (healthy non obese), group 2 (healthy obese), group 3 (non
obese with chronic periodontitis) and group 4 (obese with chronic
periodontitis). Serum and GCF PGRN levels were estimated by enzyme linked
immunosorbant assay (ELISA) and hs CRP levels were estimated by
immunoturbidimetry method. Results: The mean PGRN and hs CRP concentration both in serum and
GCF were highest for group 4 followed by group 3, group 2 and least in Group
1. Conclusion: PGRN and hs CRP may be novel biomarkers of the chronic
inflammatory response in obesity and chronic periodontitis.
Keywords: Chronic periodontitis, C reactive protein, progranulin, obesity
