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Article type: Research Article
Authors: Raghavendra, N.M. | Pradeep, A.R. | Kathariya, Rahul | Sharma, Anuj | Rao, Nishanth S. | Naik, Savitha B.
Affiliations: }Department of Periodontics, Government Dental College and Research Institute, Bangalore, India | Department of Periodontics and Oral Implantology, Dr. DY Patil Dental College and Hospital, Pune, India | Department of Conservative and Endodontics, Government Dental College and Research Institute, Bangalore, India
Note: [] Corresponding author: Dr. N.M. Raghavendra, Department of Periodontics, Govt. Dental College and Research Institute, Bangalore 560002, India. Fax: +91 080 26703176; E-mail: periodonticsgdcri@gmail.com
Abstract: Visfatin is a pleiotropic mediator which acts as growth factor, cytokine, enzyme involved in energy including nicotinamide adenine dinucleotide metabolism and has been recently demonstrated to exert several pro-inflammatory functions. The purpose of this study is to evaluate the Visfatin concentration in gingival crevicular fluid (GCF) and serum in patients with chronic periodontitis, and to evaluate the effect of non-surgical periodontal therapy on the GCF and serum visfatin concentration. 30 subjects (age range: 25 to 52 years) were selected and divided into two groups based on the gingival index, probing depth, periodontal attachment level, and radiologic parameters (bone loss): group 1 (15 subjects with healthy periodontium), group 2 (15 subjects with chronic periodontitis), while, Group 2 patients after 8 weeks of the treatment (scaling and root planning, SRP) constituted group 3. GCF samples (by microcapillary pipettes) and serum samples (by venipuncture) were collected to estimate the levels of Visfatin using enzyme linked immunosorbent assay kit. The mean Visfatin concentration in GCF and serum was observed to be the highest in group 2 and lowest in group 1. While concentration in group 3 was similar to group 1. The concentration of Visfatin in GCF and serum decreased after SRP. The Visfatin concentration in GCF and serum found to be highest in chronic periodontitis group and decreases after treatment. Hence Visfatin values can be considered as an "inflammatory marker" can be explored in future as a potential therapeutic target in the treatment of periodontal disease.
Keywords: Visfatin, gingivitis, chronic periodontitis, serum, adipokines
DOI: 10.3233/DMA-2012-0897
Journal: Disease Markers, vol. 32, no. 6, pp. 383-388, 2012
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