Affiliations: Department of Periodontics and Oral Implantology,
Oxford Dental College Hospital and Research Centre, Bangalore, India | Department of Periodontology and Oral Implantology,
Dr. D.Y. Patil Dental College and Hospital, Pune, India | Department of Periodontics, KLE'S Institute of Dental
Sciences and Research Center, Bangalore, India
Note: [] Corresponding author: Dr. Archana Devanoorkar, Senior Lecturer,
Department of Periodontics and Oral Implantology, AME'S Dental College, Raichur
584103, Karnataka, India. Tel.: +91 90369 22517/+91 93793 35197; E-mail:
dr.archanashivm@gmail.com
Abstract: Background: Resistin and adiponectin are the adipokines secreted by
adipocytes and various inflammatory cells. These adipokines are known to play
an important role in insulin resistance. The aim of this study was to determine
the serum resistin levels in periodontal health and disease and also, to
determine the effect of nonsurgical periodontal therapy on its levels. Methods: A total of 40 patients (20 Males and 20 Females; age range
20–50 years) participated in the study. Subjects were categorized as
healthy (group 1; Controls) and chronic periodontitis (group 2; Study) groups
based on their periodontal status. Periodontal parameters (Plaque index (PI),
Gingival index (GI), Bleeding index (BI), Probing pocket depth (PPD), Clinical
attachment loss (CAL)) together with serum resistin levels were assessed at
baseline and between 6–8 weeks following nonsurgical periodontal therapy
for subjects in group~2 and only at baseline in group 1.
Sera were tested in duplicate (single run), and the results were averaged. Results: Study group showed higher (1.89 ± 1.83 ng/ml) serum
resistin levels, compared to control group (1.35 ± 0.70 ng/ml). However,
this difference was not statistically significant (P=0.227). Also, resistin
levels decreased following nonsurgical periodontal therapy but, this decrease
failed to show any statistical significance, with pretreatment levels being
1.89 ± 1.83 ng/ml and post treatment levels being 1.59 ± 1.01
ng/ml (P=0.386). Conclusion: Observations of the present study revealed that there
was not much difference in the serum resistin levels between the cases and the
controls. Also the decrease in the resistin levels following nonsurgical
periodontal therapy did not show any statistical significance.
