Replication of relevant SNPs associated with cardiovascular disease susceptibility obtained from GWAs in a case-control study in a Canarian population

Article type: Research Article

Authors: Esparragón, Francisco Rodríguez^; | Companioni, Osmel | Bello, Miguel García | Ríos, Nisa Buset | Pérez, José Carlos Rodríguez^{; ;}

Affiliations: Unidad de Investigación, HIRICARE Study Group, Hospital Universitario de Gran Canaria, Las Palmas de Gran Canaria, Gran Canaria, Spain | Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Gran Canaria, Spain | Servicio de Nefrología, Hospital Universitario de Gran Canaria, Las Palmas de Gran Canaria, Gran Canaria, Spain

Note: [] Corresponding author. E-mail: frodesp@gobiernodecanarias.org

Abstract: Recent genome-wide single nucleotide polymorphism (SNP) association studies (GWAS) have identified a number of SNPs that were significantly associated with coronary artery disease (CAD) and myocardial infarction (MI). We tested for replication of the previously described association with CAD in our case-control datasets of SNPs variants located at 1p13.1, 2q33.1, 10q11.1, 9p21, and 21q22. We observed a small significant risk associated of the SNP rs10757274 with CAD in the PROCAGENE study. Besides, the multilocus combination rs10757274 and rs1333048 gave a near significant result. We confirmed that the SNP rs10757274 showed association with CAD in the PROCAGENE study, although after applying the Bonferroni correction was not longer significant. Independent replication studies in other populations are needed to unequivocally confirm the association.

Keywords: Genome-wide association studies, polymorphisms, coronary artery disease, myocardial infarction

DOI: 10.3233/DMA-2011-0879

Journal: Disease Markers, vol. 32, no. 4, pp. 231-239, 2012