Affiliations: Department of Periodontology, Gaziantep University,
Faculty of Dentistry, Gaziantep, Turkey | Department of Periodontology, Ataturk University,
Faculty of Dentistry, Erzurum, Turkey
Abstract: Background: 8-hydroxydeoxyguanosine (8-OHdG) is commonly used as a
marker to evaluate oxidative DNA damage in disorders including chronic
inflammatory diseases such as inflammatory periodontal pathologies. In the
current study we hypothesized that the level of 8-OHdG in saliva increases by
the periodontal destruction severity determined by clinical parameters as
clinical attachment level (CAL). Materials and methods: A cross-sectional
study was conducted on a sum of 60 age gender balanced; chronic periodontitis
(CP) (n=20), chronic gingivitis (CG) (n=20) and healthy (H) (n=20)
individuals. Clinical periodontal parameters and salivary 8-OHdG levels were
evaluated. Results: The mean 8-OHdG level in the saliva of the CP group
was significantly higher than H and CG groups (p< 0.001). Statistically
significant correlation was only observed between the salivary levels of 8-OHdG
and age (p< 0.05), probing depth (PD) and CAL (p< 0.001) in CP group.
However, when CP patients were classified according to their CAL levels
(CAL⩾ 3 mm (n=11) and CAL<3 mm (n=9)) statistically significant
correlation was only observed between the salivary levels of 8-OHdG and CAL
⩾ 3 mm patients (p< 0.001). Conclusion: We suggest that elevated salivary levels of 8-OHdG may be a marker for disease activity and it
may reflect indirectly disease severity parameters such as CAL.
