Searching for just a few words should be enough to get started. If you need to make more complex queries, use the tips below to guide you.
Article type: Research Article
Authors: Dodani, Sunita | Henkhaus, Rebecca | Dong, Lei | Butler, Merlin G.
Affiliations: Center for Post Polio Rehabilitation (A non-profit organization), KS, USA | Departments of Psychiatry and Behavioral Sciences and Pediatrics, University of Kansas Medical Center, KS, USA | Department of Biostatistics, University of Kansas Medical Center, KS, USA
Note: [] Correspondence: Sunita Dodani, MD, PhD, FAHA, P O Box 25246 Shawnee Mission, KS 66225, USA. Tel.: +1 913 663 2803; E-mail: soni.dodani@gmail.com
Abstract: Objectives: Coronary artery disease (CAD) is a leading cause of death globally with increasing burden in South Asians in the US. Specific genetic variants that influence CAD have not been fully assessed in South Asian Immigrants. The goal is to identify Apo lipoprotein A1 (APOA1) gene polymorphisms and their association with CAD risk factors, metabolic syndrome and dysfunctional HDL (Dys-HDL). Methods: A community-based study on South Asians aged 35--65 years without CAD was conducted. APOA1 gene sequencing was performed and genotypes compared with cardiovascular findings. Results: The prevalence of metabolic syndrome and dysfunctional-HDL was 29.7% and 26%, respectively. Six novel APOA1 gene single nucleotide peptides ({SNPs}) were analyzed. Three of the six SNPs (G2, G3, and G5) were found to be associated with metabolic syndrome; G2 (T655C) (p=0.044), G3 (T756C) (p=0.037) and G5 (T1001C) (p=0.037). APOA1 gene SNP G1 (T319C) was highly correlated with low HDL levels (p=0.001). In our study, both associations of APOA1 SNPs with metabolic syndrome and low HDL remained after age-adjustment. Conclusion: Discovery of novel gene polymorphisms will help to understand further the causes of excess CAD risk in South Asians so that preventative strategies targeted to high-risk group can be developed.
Keywords: Coronary artery disease, risk factors, South Asian immigrants, polymorphisms, Apo Lipoprotein A1, dysfunctional high density lipoprotein
DOI: 10.3233/DMA-2012-0856
Journal: Disease Markers, vol. 32, no. 1, pp. 9-19, 2012
IOS Press, Inc.
6751 Tepper Drive
Clifton, VA 20124
USA
Tel: +1 703 830 6300
Fax: +1 703 830 2300
sales@iospress.com
For editorial issues, like the status of your submitted paper or proposals, write to editorial@iospress.nl
IOS Press
Nieuwe Hemweg 6B
1013 BG Amsterdam
The Netherlands
Tel: +31 20 688 3355
Fax: +31 20 687 0091
info@iospress.nl
For editorial issues, permissions, book requests, submissions and proceedings, contact the Amsterdam office info@iospress.nl
Inspirees International (China Office)
Ciyunsi Beili 207(CapitaLand), Bld 1, 7-901
100025, Beijing
China
Free service line: 400 661 8717
Fax: +86 10 8446 7947
china@iospress.cn
For editorial issues, like the status of your submitted paper or proposals, write to editorial@iospress.nl
如果您在出版方面需要帮助或有任何建, 件至: editorial@iospress.nl