Affiliations: Ege University, School of Dentistry, Department of
Periodontology, Izmir, Turkey | Celal Bayar University, School of Science, Department
of Biology, Manisa, Turkey
Note: [] Corresponding author: Gülnur Emingil, DDS, PhD, Ege
University, School of Dentistry, Department of Periodontology, Bornova-35100,
Izmir-Turkey. Tel.: +90 232 388 1105; Fax: +90 232 388 0325; E-mail:
gemingil@yahoo.com
Abstract: Aim: The aim of the present study was to investigate gingival
crevicular fluid (GCF) calprotectin, osteocalcin and cross-linked N-terminal
telopeptide (NTx) levels in health along with different periodontal diseases. Material and methods: Twenty chronic periodontitis (CP), 20 generalized
aggressive periodontitis (G-AgP), 20 gingivitis and 20 healthy subjects were
included. Probing depth, clinical attachment level, plaque index and papillary
bleeding index was recorded. GCF calprotectin, osteocalcin and NTx levels were
analyzed by enzyme-linked immunosorbent assay (ELISA). Results: CP, G-AgP and gingivitis groups had higher GCF calprotectin total amount compared to
healthy subjects (p< 0.008). CP and G-AgP groups had similar, but higher
levels compared to gingivitis groups (p< 0.008). CP and G-AgP groups had
lower GCF osteocalcin total amount compared to gingivitis and healthy groups
(p< 0.008). CP group had higher GCF NTx but lower osteocalcin total amount
and osteocalcin/NTx ratio than the G-AgP group (p< 0.008). Conclusions: Our results suggest that elevated GCF calprotectin levels play a
role as a reliable inflammatory marker in the pathogenesis of periodontal
disease. Fluctuating GCF levels of osteocalcin and NTx might point out to the
abnormal bone turnover in periodontitis. Our data document for the first time
the role of NTx in the pathogenesis of different periodontal diseases.
Keywords: Calprotectin, osteocalcin and NTx in periodontitis
