Searching for just a few words should be enough to get started. If you need to make more complex queries, use the tips below to guide you.
Article type: Research Article
Authors: Salem, Abdel Halim; | Yaqoob, Alaeddin | Ali, Muhalab | Handu, Shailandra | Fadel, Raouf; | Abu-Hijleh, Marwan | Almawi, Wassim
Affiliations: Department of Anatomy, College of Medicine and Medical Sciences, Arabian Gulf University, Manama, Bahrain | Department of Anatomy, Faculty of Medicine, Suez Canal University, Ismailia, Egypt | Salmaniya Medical Complex, Ministry of Health, Manama, Bahrain | Department of Biochemistry, College of Medicine and Medical Sciences, Arabian Gulf University, Manama, Bahrain | Department of Pharmacology and Therapeutics, College of Medicine and Medical Sciences, Arabian Gulf University, Manama, Bahrain
Note: [] Address for correspondence: Dr. Abdel Halim Salem, Department of Anatomy, College of Medicine and Medical Sciences, Arabian Gulf University, 22979 Manama, Kingdom of Bahrain. Tel.: +973 17239650; Fax: +973 17271090; E-mail: ahaleemfd@agu.edu.bh
Abstract: Deletion polymorphisms for the glutathione S-transferase (GST) gene are associated with increased risk of cancer, and are implicated in detoxifying mutagenic electrophilic compounds. GST Polymorphic variants were reported for different populations. The aim of this study was to investigate the frequencies of GSTM1 and GSTT1 null genotypes among Bahraini, Lebanese and Tunisian Arabs. GST genotyping was done by multiplex PCR-based methods. Study subjects comprised 167 Bahrainis, 141 Lebanese and 186 Tunisians unrelated healthy individuals. GSTM1 deletion homozygosity of 49.7%, 52.5% and 63.4% were recorded for Bahraini, Lebanese and Tunisians, respectively. Among Bahrainis, the prevalence of GSTT1 null homozygotes was 28.7%, while in higher rates were seen in Lebanese (37.6%) and Tunisians (37.1%). Our results indicate that there are no major differences in allelic distribution of GSTM1 and GSTT1 genes between the three Arab populations investigated except between Bahrainis and Tunisians regarding the allelic distribution of GSTM1 gene (P=0.013). Combined analysis of both genes revealed that 14.4% of Bahrainis, 16.3% of Lebanese and 21.0% of Tunisians harbor the deleted genotype of both genes. This is the first study that addresses GST gene polymorphism in Bahraini and Lebanese Arabs, and will help genetic studies on the association of GSTM1 and GSTT1 polymorphisms with disease risks and drug effects in Arab populations.
Keywords: Glutathione S-transferase, genetic polymorphisms, Arabs
DOI: 10.3233/DMA-2011-0845
Journal: Disease Markers, vol. 31, no. 5, pp. 311-316, 2011
IOS Press, Inc.
6751 Tepper Drive
Clifton, VA 20124
USA
Tel: +1 703 830 6300
Fax: +1 703 830 2300
sales@iospress.com
For editorial issues, like the status of your submitted paper or proposals, write to editorial@iospress.nl
IOS Press
Nieuwe Hemweg 6B
1013 BG Amsterdam
The Netherlands
Tel: +31 20 688 3355
Fax: +31 20 687 0091
info@iospress.nl
For editorial issues, permissions, book requests, submissions and proceedings, contact the Amsterdam office info@iospress.nl
Inspirees International (China Office)
Ciyunsi Beili 207(CapitaLand), Bld 1, 7-901
100025, Beijing
China
Free service line: 400 661 8717
Fax: +86 10 8446 7947
china@iospress.cn
For editorial issues, like the status of your submitted paper or proposals, write to editorial@iospress.nl
如果您在出版方面需要帮助或有任何建, 件至: editorial@iospress.nl