Article type: Research Article
Authors: Huang, Yuli | Hu, Yunzhao | Mai, Weiyi | Cai, Xiaoyan | Song, Yuanbin | Wu, Yanxian | Dong, Yugang | Huang, Huiling | He, Zhongyun | Li, Wensheng | Yang, You | Rao, Shaoqi
Affiliations: Department of Cardiology, the Affiliated Hospital at
Shunde (the First People's Hospital of Shunde), Southern Medical University, P.R. China | Department of Cardiology, the First Affiliated
Hospital of Sun Yat-sen University, Guangzhou, P.R. China | Department of Burn, the First People's Hospital of
Shunde, Foshan, P.R. China
Note: [] Corresponding author: Professor Yunzhao Hu, Department of
Cardiology, the Affiliated Hospital at Shunde (the First People's Hospital of
Shunde), Southern Medical University, Penglai Road, Daliang Town, Shunde
District, Foshan, 528300, P.R. China. Tel.: +86 757 22318680; Fax: +86 757
22223899; E-mail: hyz.4406@medmail.com.cn
Abstract: Objectives: Oxidized low-density lipoprotein (ox-LDL) is considered
to be a key factor of initiating and accelerating atherosclerosis. The
objective of this study was to investigate the role of ox-LDL in young patients
with coronary artery disease (CAD). Methods: 128 consecutive angiographically proven young CAD patients (aged ⩽ 55 years) were
enrolled, and 132 age-matched non-CAD individuals (coronary angiography normal
or negative finding by coronary ultrafast CT) were set as control group.
Conventional risk factors (hypertension, dyslipidemia, diabetes mellitus,
obesity, smoking) were evaluated in the two groups. Ox-LDL was measured by
competitive ELISA. Framingham risk score (FRS) and absolute 10-year CAD events
risk were calculated for each individual. Results: Male sex was more prevalent in group CAD than in control (87.5% vs. 62.1%; P<
0.01). There were significant differences in smoking history (P< 0.01) and
triglyeride (TG) and ratio of apolipoprotein B/apolipoprotein A1 (ApoB/ApoA1)
(both P< 0.05) but no remarkable difference in other conventional risk
factors (all P> 0.05) between group CAD and control. Level of ox-LDL was
significantly higher in group CAD than in control (P< 0.01). Multivariate
logistic regression showed that male sex (OR, 4.54; 95%CI, 1.76–9.77),
smoking quantity (OR, 2.78; 95%CI, 1.34–4.25), TG (OR, 1.42; 95%CI,
1.18–2.83), ApoB/ApoA1 (OR, 1.73; 95%CI, 1.32–4.23), and ox-LDL (OR, 2.15;
95%CI, 1.37–6.95) were independently correlated with CAD in young patients.
Area under the curve (AUC) of receiver operating characteristic (ROC) curve of
TG, ApoB/ApoA1, and ox-LDL was 0.831, 0.866, and 0.935, respectively (P< 0.001). Conclusions: Ox-LDL is an important independent risk factor for
CAD in young patients after adjusting other risk factors such as smoking, TG, and ApoB/ApoA1.
Keywords: Risk factors, young, coronary artery disease, oxidized low-density lipoprotein
DOI: 10.3233/DMA-2011-0832
Journal: Disease Markers, vol. 31, no. 5, pp. 295-301, 2011
Received 14 October 2011
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Accepted 14 October 2011
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Published: 2011
