Affiliations: Department of Nephrology, Affiliated the No.1 People's
Hospital of Huaian, Nanjing Medical university, Huaian, Jiangsu, P.R.
China | Department of Cardiology, Affiliated the No.1 People's
Hospital of Huaian, Nanjing Medical university, Huaian, Jiangsu, P.R.
China
Note: [] Corresponding author: Feng-Ying Tang, Department of Nephrology,
Affiliated the No.1 People's Hospital of Huaian, Nanjing Medical university,
Huaian, Jiangsu, P.R. China. The Beijing Xi Road No.6, Huaian, 223300, Jiangsu,
P.R. China. E-mail: tangfengying_1976@yahoo.com.cn
Abstract: Background: The development of cardiovascular disease in ESRD
patients is considered to be associated with oxidative stress. NAD(P)H oxidase
has attracted attention as mechanisms of generating oxidative stress. We
investigated the relation between the genotype of the C242T CYBA polymorphism
of the NADPH oxidase and the development of cardiovascular disease in ESRD
patients. Methods: A total of 289 ESRD patients were recruited and allocated
to one of the two groups: patients without cardiovascular disease (group N;
n=192) and patients developing cardiovascular disease (group D; n=97). The
C242T CYBA polymorphism was determined by RFLP-PCR methods. Results: The frequency of the C242T CT+TT genotype was significantly
lower in group D than in group N (9.1 vs. 20.2%). In multiple Logistic
regression analysis, systolic blood pressure, smoking history and this gene
polymorphism were shown to be independent variables for the development of
cardiovascular disease in ESRD patients. Conclusions: These results suggest that assessment of the C242T CYBA
polymorphism of the NADPH oxidase may be useful in identifying the risk for
developing cardiovascular disease in ESRD patients.
