Affiliations: Department of Genetics, Sanjay Gandhi Post Graduate
Institute of Medical Sciences (SGPGIMS), Lucknow, India | Department of Cardiology, Sanjay Gandhi Post Graduate
Institute of Medical Sciences (SGPGIMS), Lucknow, India
Note: [] Corresponding author: Dr. Balraj Mittal (Professor), Department
of Genetics, SGPGIMS, Lucknow-226014 (U P) India. Fax: +91 522 2668017/2668973;
E-mail: balraj@sgpgi.ac.in; bml_pgi@yahoo.com
Abstract: Background: ATP-binding cassette transporter ABCG8 plays an
important role in excretion of cholesterol from liver. Common genetic
polymorphisms in ABCG8 gene may genetically predispose an individual to
coronary artery disease (CAD) along with response to atorvastatin therapy.
Thus, we aimed to examine the role of ABCG8 D19H polymorphism (rs11887534) in
susceptibility to CAD and its influence on atorvastatin response. Methodology: The study included 213 CAD patients and 220 controls.
Genotyping of ABCG8 D19H polymorphism was done by PCR-RFLP. Results} Our results showed that ABCG8 'H' allele was conferring
significant risk for CAD in a dominant model (OR=2.54; p=0.014). This increased
risk for CAD was more pronounced in males (OR=2.69; p=0.030). No correlation of
ABCG8 genotypes with the risk factors (diabetes, hypertension and smoking) of
CAD was observed. On atorvastatin treatment there was a significant decrease in
the LDL-C levels (p=0.021). However, stepwise multiple regression analysis
showed that this decease was not associated with ABCG8 genetic variant
(p=0.845). Observed determinants of variation in interindividual response to
atorvastatin therapy were pre-treatment LDL-C (p= 0.024) and TC (p=0.017). Conclusion: Although the genetic variant 19H of ABCG8 confers risk
for CAD in North Indian population, it is not associated with interindividual
response to atorvastatin therapy.
