Searching for just a few words should be enough to get started. If you need to make more complex queries, use the tips below to guide you.
Article type: Research Article
Authors: Sambasivan, Venkatasubramanian | Murthy, Kolluri Janaki Rama | Reddy, Ravindra | Vijayalakshimi, Valluri; | Hasan, Qurratulain;
Affiliations: Department of Genetics, Bhagwan Mahavir Medical Research Centre, 10-1-1, A.C. Guards, Hyderabad, 500004, India | Department of Immunology, Bhagwan Mahavir Medical Research Centre, 10-1-1, A.C. Guards, Hyderabad, 500004, India | Blue Peter Research Centre, Cherlapally, Hyderabad, 501301, India | Department of Genetics & Molecular Medicine, Kamineni Hospitals. L.B. Nagar, Hyderabad, 500068, India | Department of Pulmonology, Kamineni Hospitals. L.B. Nagar, Hyderabad, 500068, India
Note: [] Corresponding author: Dr. Q. Hasan, Senior Consultant, Department of Genetics and Molecular Medicine, Kamineni Hospital, L.B. Nagar, Hyderabad- 500068, India. Tel.: +91 40 24022272 76 Ext: 210; Fax: +91 40 24022277; E-mail: qhasan2000@yahoo.com
Abstract: Objective: Pulmonary tuberculosis (PTB) is a leading cause of morbidity and mortality. Macrophages play an important role in the immunopathogenesis of tuberculosis. Extracellular ATP induces macrophage bactericidal activity through activation of the purinergic P2X7 receptor. This case- control study assesses the association of −762 T/C, 1513A/C and 1729T/A P2X7 polymorphisms in patients with PTB and healthy controls to establish association if any with risk of developing the disease. Materials and methods: The genotyping for P2X7 was carried out using PCR and RFLP analysis in 256 individuals, which included 156 active PTB patients and 100 age and sex, matched healthy volunteers with no clinical symptoms or family history of PTB as controls. Results: A chi square test showed a significant difference between the PTB patient and controls for −762 C allele; p=0.0051 (OR 1.6972, CI 95% 1.1839 to 2.4332) and1729 T allele was found to be positively associated with the PTB; p < 0.0005 (OR- 2.4623, CI 95% 1.6376 to 3.7022). 1513A/C polymorphism did not show any significant difference between the two groups. Significance: The study revealed a significant association of P2X7-762C allele and P2X7 1729T allele receptor polymorphisms with PTB in Asian Indian population. The use of these alleles as biomarkers for identifying individuals at high risk of developing TB needs to be ascertained.
Keywords: Tuberculosis, P2X7 Gene polymorphisms, Mycobacterium tuberculosis, Purinergic Receptor
DOI: 10.3233/DMA-2010-0682
Journal: Disease Markers, vol. 28, no. 1, pp. 43-48, 2010
IOS Press, Inc.
6751 Tepper Drive
Clifton, VA 20124
USA
Tel: +1 703 830 6300
Fax: +1 703 830 2300
sales@iospress.com
For editorial issues, like the status of your submitted paper or proposals, write to editorial@iospress.nl
IOS Press
Nieuwe Hemweg 6B
1013 BG Amsterdam
The Netherlands
Tel: +31 20 688 3355
Fax: +31 20 687 0091
info@iospress.nl
For editorial issues, permissions, book requests, submissions and proceedings, contact the Amsterdam office info@iospress.nl
Inspirees International (China Office)
Ciyunsi Beili 207(CapitaLand), Bld 1, 7-901
100025, Beijing
China
Free service line: 400 661 8717
Fax: +86 10 8446 7947
china@iospress.cn
For editorial issues, like the status of your submitted paper or proposals, write to editorial@iospress.nl
如果您在出版方面需要帮助或有任何建, 件至: editorial@iospress.nl