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Issue title: Molecular Markers of Infectious Diseases
Article type: Research Article
Authors: Mascellino, M.T. | Margani, M. | Oliva, A.
Affiliations: Policlinico Umberto I, Roma, Italy
Note: [] Corresponding author: Maria Teresa Mascellino, Policlinico Umberto I, Viale del Policlinico 155, 00161 Roma, Italy. Tel.: +39 06 49970880; Fax: +39 06 49972628; E-mail: mariateresa. mascellino@uniroma1.it
Abstract: In this review, we examine the main virulence determinants in Helicobacter pylori (Hp) strains and the correlation between these and the different diseases following Hp infections. We also discuss the host response to Hp and the implications and advantages of the development of non-invasive pre-endoscopy screening of molecular and serological markers associated with Hp virulence and disease progression putting an emphasis on new screening techniques such as the Luminex – X multi analytes profiling technology and the multiplex PCR.
Keywords: Virulence determinants, Helicobacter pylori-associated infections, immune response and immunopathology, serological markers, multiplex PCR
DOI: 10.3233/DMA-2009-0658
Journal: Disease Markers, vol. 27, no. 3-4, pp. 137-156, 2009
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