Affiliations: Department of Public Health, Aichi Medical University
School of Medicine, Nagakute, Japan | Department of Radiobiology/Molecular Epidemiology,
Radiation Effects Research Foundation, Hiroshima, Japan | Department of Preventive Medicine/Biostatistics and
Medical Decision Making, Nagoya University Graduate School of Medicine, Nagoya,
Japan | Department of Epidemiology for Community Health and
Medicine, Kyoto Prefectural University of Medicine Graduate School of Medical
Science, Kyoto, Japan | Division of Public Health, Department of Food and
Health Sciences, Faculty of Human Life Sciences, Jissen Women's University,
Tokyo, Japan | Aichi Cancer Center Research Institute, Nagoya,
Japan
Note: [] Corresponding author: Yingsong Lin, Department of Public Health,
Aichi Medical University School of Medicine, Japan. Tel.: +81 561 62 3311 Fax:
+81 561 62 5270; E-mail: linys@aichi-med-u.ac.jp
Abstract: Elevated serum or plasma Transforming Growth Factor-β1 (TGF-β1) {levels have been} linked to
cancer and other diseases in numerous studies; however, very few studies have
reported an association between circulating TGF-β1 and
lifestyle factors in healthy people. We examined the association between serum
TGF-β1 levels and gender, age, body mass index (BMI),
smoking, and drinking in a large population-based cohort study (N
=9,142). Serum TGF-β1 levels were
{detected by the Quantikine enzyme-linked immunoassay kit (R&D Systems).
The data indicated highly significant (p< ;0.0001) difference
in serum TGF-β1 levels between men (mean value: 37.6
± 0.12 ng/mL, N=4888) and women
(mean value: 35.1 ± 0.12 ng/ml, N=4254).} Serum TGF-β1 levels decreased with age (trend
p< 0.0001) and were positively associated with obesity
(trend p< 0.0001) in both men and women. We observed a
significant trend with increased serum TGF-β1 levels
corresponding to increased amount of tobacco and alcohol consumption in men
(trend p< 0.0001). These findings suggest that serum
TGF-β1 levels appear to be modulated by {gender}, age
and lifestyle factors such as obesity, cigarette smoking, and alcohol drinking
in healthy Japanese adults.
