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Article type: Research Article
Authors: Wang, Chao-Jie | Zhou, Zong-Guang | Wang, Ling | Yang, Lie | Zhou, Bin | Gu, Jun | Chen, Hong-Ying | Sun, Xiao-Feng;
Affiliations: Institute of Digestive Surgery and Department of Colorectal Surgery, and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China | Department of Oncology, Institute of Clinical and Experimental Medicine, University of Linköping, Linköping, Sweden
Note: [] Corresponding author: Xiao-Feng Sun, Prof., MD, PhD, lecture professor of "Cheung Kong Scholars" of Sichuan University. Institute of Digestive Surgery, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China. Tel.: +86 28 85164035; Fax: +86 28 85164035. Department of Oncology, Institute of Clinical and Experimental Medicine, University of Linköping, S-581 85 Linköping, Sweden. Tel.: +46 13 222066; Fax: +46 13 223090; E-mail: xiasu@ibk.liu.se
Abstract: We are just beginning to understand how microRNAs (miRNAs) are involved in tumor-related processes in humans. Applying real-time RT-PCR, we investigated the miR-31, miR-143 and miR-145 expression in 98 primary CRC specimens, along with the corresponding normal mucosa specimens, and analyze the relationship of their expression with clinicopathological features. Our results showed the miR-31 expression was up-regulated in CRC compared to normal mucosa (p = 0.001). Furthermore, miR-31 expression was positively related to advanced TNM stage (p = 0.026) and deeper invasion of tumors (p = 0.024). MiR-145 was down-regulated in both colon (p = 0.001) and rectal (p = 0.012) cancer. MiR-143 was only down-regulated in colon cancer (p = 0.023) but not in rectal cancer (p = 0.351). There was no relationship of miR-143 and miR-145 expression with other clinicopathological features (p > 0.05), except that the miR-145 expression was related to cancer site (p = 0.03). In conclusion, the miR-31 overexpression may be involved in the development and progression of CRC. The miR-143 and miR-145 may play a certain role in the development of colon and/or rectal cancers but not in progression of the disease.
Keywords: microRNA, colorectal cancer, tumor stage, real-time RT-PCR
DOI: 10.3233/DMA-2009-0601
Journal: Disease Markers, vol. 26, no. 1, pp. 27-34, 2009
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