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Article type: Research Article
Authors: Ferro, Anabela; | Castro, Maria-José; ; | Lemos, Carolina; ; | Santos, Mónica; | Sousa, Alda; | Pereira-Monteiro, José | Sequeiros, Jorge; | Maciel, Patrícia
Affiliations: UnIGENe-IBMC, Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal | Departamento de Estudo das Populações, ICBAS, Universidade do Porto, Porto, Portugal | Centro de Estudo de Cefaleias, Hospital Geral Santo António, Porto, Portugal | Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, Portugal
Note: [] Corresponding author: Patricia Maciel, Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Campus de Gualtar, 4710-057 Braga, Portugal. Tel.: +351 253 60 48 24; Fax: +351 253 60 48 20; E-mail: pmaciel@ecsaude.uminho.pt
Abstract: Migraine is a debilitating disorder affecting a large proportion of the population. The effect of methylenetrathydrofolate reductase (GeneID: 4524) polymorphisms in migraine etiology and development has been a theme of great interest. Several populations were evaluated with contradictory results. In this case-control study, we investigated the effect of the C677T polymorphism in MTHFR, as a genetic risk factor for migraine, in the Portuguese population. We observed that, overall, there was no significant difference in the frequencies of MTHFR C677T genotypes or of the T-allele among the Portuguese migraineurs when compared to controls. There was also no association of migraine with aura with MTHFR genotypes or with the T-allele, in contrast with previous studies. Regarding the risk of the T-allele homozygote carriers, there was an equal probability to develop migraine with aura over migraine without aura in our patients. Thus, we conclude that the C677T MTHFR polymorphism, responsible for a reduction of the MTHFR activity in folate metabolism, is not a major genetic susceptibility factor for migraine in the Portuguese population.
Keywords: Migraine with aura, association study, folate metabolism, homocysteine, cephalalgia
Journal: Disease Markers, vol. 25, no. 2, pp. 107-113, 2008
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