Searching for just a few words should be enough to get started. If you need to make more complex queries, use the tips below to guide you.
Issue title: STEM CELLS AND DISEASE
Article type: Research Article
Authors: Pine, Sharon R. | Marshall, Blair | Varticovski, Lyuba
Affiliations: Center for Cancer Research, NCI, NIH, Bethesda, MD, USA | Georgetown University, Washington, DC, USA
Note: [] Corresponding author: Lyuba Varticovski, MD, Center for Cancer Research, LHC, Building 37, Room 3060, National Cancer Institute, Bethesda, MD 20892, USA. E-mail: varticol@mail.nih.gov
Abstract: Lung cancer remains a major cause of cancer-related lethality because of high incidence and recurrence in spite of significant advances in staging and therapies. Recent data indicates that stem cells situated throughout the airways may initiate cancer formation. These putative stem cells maintain protumorigenic characteristics including high proliferative capacity, multipotent differentiation, drug resistance and long lifespan relative to other cells. Stem cell signaling and differentiation pathways are maintained within distinct cancer types, and destabilization of this machinery may participate in maintenance of cancer stem cells. Characterization of lung cancer stem cells is an area of active research and is critical for developing novel therapies. This review summarizes the current knowledge on stem cell signaling pathways and cell markers used to identify the lung cancer stem cells.
Keywords: ABC transporters, drug resistance, hedgehog, notch, non-small cell lung cancer, side population, small cell lung cancer, stem cells, Wnt
Journal: Disease Markers, vol. 24, no. 4-5, pp. 257-266, 2008
IOS Press, Inc.
6751 Tepper Drive
Clifton, VA 20124
USA
Tel: +1 703 830 6300
Fax: +1 703 830 2300
sales@iospress.com
For editorial issues, like the status of your submitted paper or proposals, write to editorial@iospress.nl
IOS Press
Nieuwe Hemweg 6B
1013 BG Amsterdam
The Netherlands
Tel: +31 20 688 3355
Fax: +31 20 687 0091
info@iospress.nl
For editorial issues, permissions, book requests, submissions and proceedings, contact the Amsterdam office info@iospress.nl
Inspirees International (China Office)
Ciyunsi Beili 207(CapitaLand), Bld 1, 7-901
100025, Beijing
China
Free service line: 400 661 8717
Fax: +86 10 8446 7947
china@iospress.cn
For editorial issues, like the status of your submitted paper or proposals, write to editorial@iospress.nl
如果您在出版方面需要帮助或有任何建, 件至: editorial@iospress.nl