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Issue title: Biomarkers in Multiple Sclerosis
Article type: Research Article
Authors: Giovannoni, Gavin
Affiliations: Department of Neuroinflammation, Institute of Neurology, University College London, Queen Square, London, UK
Note: [] Corresponding author: Department of Neuroinflammation, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK. Tel.: +44 (0)20 7837 3611; Fax: +44 (0)20 7837 8553; E-mail: G.Giovannoni@ion.ucl.ac.uk
Abstract: Cerebrospinal fluid (CSF) is the body fluid closest to the pathology of multiple sclerosis (MS). For many candidate biomarkers CSF is the only fluid that can be investigated. Several factors need to be standardized when sampling CSF for biomarker research: time/volume of CSF collection, sample processing/storage, and the temporal relationship of sampling to clinical or MRI markers of disease activity. Assays used for biomarker detection must be validated so as to optimize the power of the studies. A formal method for establishing whether or not a particular biomarker can be used as a surrogate end-point needs to be adopted. This process is similar to that used in clinical trials, where the reporting of studies has to be done in a standardized way with sufficient detail to permit a critical review of the study and to enable others to reproduce the study design. A commitment must be made to report negative studies so as to prevent publication bias. Pre-defined consensus criteria need to be developed for MS-related prognostic biomarkers. Currently no candidate biomarker is suitable as a surrogate end-point. Bulk biomarkers of the neurodegenerative process such as glial fibrillary acidic protein (GFAP) and neurofilaments (NF) have advantages over intermittent inflammatory markers.
Keywords: Multiple sclerosis, interferon beta, glatiramer acetate neutralizing antibodies, immune tolerance
Journal: Disease Markers, vol. 22, no. 4, pp. 187-196, 2006
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