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Article type: Research Article
Authors: Oguz, Fatma Savran | Ocal, Lale | Diler, Ali Sarper | Ozkul, Hilmi | Asicioglu, Faruk | Kasapoglu, Esen | Bozkurt, Gokay | Konice, Meral | Carin, Mahmut
Affiliations: Istanbul University, Istanbul Medical Faculty, Department of Medical Biology Istanbul, Turkey | Istanbul University, Istanbul Medical School, Department of Internal Medicine, Division of Rheumatology, Istanbul, Turkey | Trakya University Medical Faculty, Department of Medical Biology. Edirne, Turkey
Note: [] Corresponding author: Dr. Fatma Savran Oguz, Istanbul University, Istanbul Faculty of Medicine, Department of Medical Biology and Bone Marrow Bank, Capa 34390-Istanbul, Turkey. E-mail: oguzsf@usa.net
Abstract: The frequency and the distribution of HLA-B27 subtypes in spondylarthropathy (SpA) patients and controls were investigated in a sample Turkish population. B27 subtyping was performed by PCR-SSP method in two groups: 49 unrelated HLA-B27 positive Turkish patients with the diagnosis of SpA according to the European Spondyloarthropathy Study Group Criteria, and 55 HLA-B27 positive healthy controls. The frequency of HLA-B*27 was 2.6% in the Turkish population, and B*2705 was the predominant allele among patients with SpA. The difference was mainly between male patients and male controls The proportion of B*2705 among B27-positive patients and controls was significantly different (P = 0.02). Our study supports other reports from different populations which showed that B*2705 and B*2702 were more frequent in Caucasian patients with SpA.
Keywords: spondyloarthropathy, HLA-B27
Journal: Disease Markers, vol. 20, no. 6, pp. 309-312, 2004
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