Affiliations: Laboratory of Proteomics and Analytical Technologies,
SAIC-Frederick Inc., National Cancer Institute at Frederick, P.O. Box B,
Frederick, MD 21702, USA. Tel.: +1 301 846 7286; Fax: +1 301 846 6037; E-mail:
veenstra@ncifcrf.gov
Note: [] Corresponding author: Dr. Timothy D. Veenstra, Biomedical
Proteomics Program, SAIC-Frederick Inc., National Cancer Institute at
Frederick, P.O. Box B, Frederick, MD 21702-1201, USA. Tel.: +1 301 846 7286;
Fax: +1 301 846 6037; E-mail: veenstra@ncifcrf.gov
Abstract: The ability to interrogate thousands of proteins found in complex
biological samples using proteomic technologies has brought the hope of
discovering novel disease-specific biomarkers. While most proteomic
technologies used to discover diagnostic biomarkers are quite sophisticated,
"proteomic pattern analysis" has emerged as a simple, yet potentially
revolutionary, method for the early diagnosis of diseases. Utilizing this
technology, hundreds of clinical samples can be analyzed per day and several
preliminary studies suggest proteomic pattern analysis has the potential to be
a novel, highly sensitive diagnostic tool for the early detection of
cancer.
Keywords: proteomic patterns, cancer detection, serum, mass spectrometry
Journal: Disease Markers, vol. 19, no. 4-5, pp. 209-218, 2003,2004
