Analysis of expression patterns: The scope of the problem, the problem of scope

Article type: Research Article

Authors: Chen, Yidong | Yakhini, Zohar | Ben-Dor, Amir | Dougherty, Edward | Trent, Jeffrey M. | Bittner, Michael

Affiliations: Cancer Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA | Chemical and Biological Systems Department, Agilent Laboratories, Palo Alto, CA 94304, USA | Department of Electrical Engineering, Texas A & M University, College Station, TX 77843, USA

Note: [] NHGRI/NIH, Building 49, Room 4A52, 9000 Rockville Pike, Bethesda, MD 20850, USA. Tel.: +1 301 496 7980; Fax: +1 301 402 3241; E-mail: mbittner@nhgri.nih.gov

Abstract: Studies of the expression patterns of many genes simultaneously lead to the observation that even in closely related pathologies, there are numerous genes that are differentially expressed in consistent patterns correlated to each sample type. The early uses of the enabling technology, microarrays, was focused on gathering mechanistic biological insights. The early findings now pose another clear challenge, finding ways to effectively use this kind of information to develop diagnostics.

Journal: Disease Markers, vol. 17, no. 2, pp. 59-65, 2001