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Article type: Research Article
Authors: Devine, Peter L. | Siebert, Wendy J. | Morton, Sharon L. | Scells, Betty | Quin, Rachel J. | Heddle, William F. | Zimmerman, Paul V. | Donohoe, Peter J.
Affiliations: Department of Obstetrics & Gynaecology, University of Queensland, Brisbane, Australia | Department of Pharmacy, Flinders Medical Centre, Adelaide, Australia | Department of Medicine, Flinders Medical Centre, Adelaide, Australia | Department of Thoracic Medicine, Prince Charles Hospital, Chermside, Queensland, Australia | Department of Immunology, Allergy and Arthritis, Flinders Medical Centre, Adelaide, Australia
Note: [] Correspondence: Wendy J. Siebert, Flinders Medical Centre, Bedford Park, S. Australia, 5042, Tel.: + 61 8 8204 5511, Fax: +61 8 8204 5841
Abstract: Amiodarone is used to treat life-threatening cardiac arrhythmias. Amiodarone-induced pulmonary toxicity (APT) can be difficult to diagnose. APT may result in increased mucus production and mucin expression. Thus, serum mucin-1 was evaluated as a marker for amiodarone-induced pulmonary toxicity. Concentrations of mucin-1 in peripheral blood were determined using cancer-associated serum antigen (CASA) assay in patients taking amiodarone. Eight of ten patients who developed major amiodarone toxicity had high serum CASA levels. Patients with toxicity had a significantly higher mean rank CASA concentration compared with those without major toxicity. CASA shows potential as a marker for amiodarone-induced toxicity, particularly pulmonary toxicity.
Keywords: mucin, CASA, amiodarone, pulmonary toxicity
Journal: Disease Markers, vol. 14, no. 3, pp. 169-175, 1998
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