Phosphotyrosine-Protein-Phosphatase and Diabetic Disorders.
Further Studies on the Relationship between Low Molecular Weight Acid
Phosphatase Genotype and Degree of Glycemic Control
Affiliations: Department of MCA Biology, University of Camerino,
School of Science, Camerino, Italy | Center of Diabetology, USSL, Penne, Italy | Chair of Allergology and Clinical Immunology,
University of Rome Tor Vergata, School of Medicine, Rome, Italy | Chair of Preventive and Social Pediatrics, University
of Rome Tor Vergata, School of Medicine, Rome, Italy
Note: [] Correspondence: Fulvia Gloria-Bottini MD, Dipartimento di
Biopatologia e Diagnostica per Immagini, Università degli Studi di Roma
Tor Vergata, Via della Ricerca Scientifica, I-00133 Roma, Italy, Tel.: +39 6
72596030, Fax: +39 6 72596028, E-mail: bottini@med.uniroma2.it.
Abstract: We have studied a new sample of 276 NIDDM patients from the
population of Penne (Italy). Comparison of the new data with those of 214
diabetic pregnant women from the population of Rome reported in a previous
paper has shown that the pattern of association between low molecular weight
acid phosphatase genotype and degree of glycemic control is similar in the two
classes of diabetic patients. Among nonobese subjects the proportion of ACP1*A
(the allele showing the lowest enzymatic activity) is lower in diabetic
patients with high glycemic levels (mean value greater than 8.9 mmol/l) than in
diabetic patients with a low glycemic level (mean value less than 8.9 mmol/l).
Among obese subjects no significant association is observed between glycemic
levels and ACP1. Among nonobese subjects the concentration of f isoform of ACP1
is higher in patients showing a high glycemic level than in patients showing a
low glycemic level. No significant difference is observed for s isoform.
