Erythrocytes aggregation in healthy donors at native and standard hematocrit: The influence of sex, age, immunoglobulins and fibrinogen concentrations. Standardization of parameters

Article type: Research Article

Authors: Korotaeva, T.V. | Firsov, N.N. | Bjelle, A. | Vishlova, M.A.

Affiliations: Institute of Rheumatology, Moscow, Russia | Russian State Medical University, Moscow, Russia | Rheumatology Department, Gothenburg University, Gothenburg, Sweden

Abstract: Characteristic parameters of erythrocyte aggregation/disaggregation kinetics in blood samples of 200 healthy donors at native and standard hematocrit were studied. Average aggregation parameters for men and women at native hematocrit significantly differed, but these differences disappeared after hematocrit standardization, only maximal amplitude of aggregation (I0) at standard hematocrit in women was still less than in men (p<0.001). Though index of strength of largest aggregates (Ia2.5) depended both on sex and age, no significant influence of IgG and IgM concentrations on this parameter was noticed. The obtained results show that suggested method can be used for diagnostics of rheological disorders.

Journal: Clinical Hemorheology and Microcirculation, vol. 36, no. 4, pp. 335-343, 2007