Affiliations: Department of Operative Techniques and Surgical Research, Medical and Health Science Centre, Faculty of Medicine, University of Debrecen, Debrecen, Hungary | Department of Anaesthesiology and Intensive Care Medicine, Martin Luther University Halle-Wittenberg, Halle/Saale, Germany | Department of Neurosurgery, Martin Luther University Halle-Wittenberg, Halle/Saale, Germany
Note: [] Corresponding author: Norbert Nemeth, MD, PhD, Department of Operative Techniques and Surgical Research, Medical and Health Science Centre, University of Debrecen, H-4032 Debrecen, Nagyerdei krt. 98., Hungary. Tel./Fax: +36 52 416 915; E-mail: nemeth@jaguar.unideb.hu.
Abstract: Using a well defined pig model, we investigated whether cerebral hypertension and hypotension influence hemorheological factors. After surgical preparation and stabilization, periods of hyperventilation, controlled periods of cerebral perfusion pressure increases and decreases were utilized. After each period, blood samples were collected from the cannulated femoral artery and vein, and from the superior sagittal sinus. Erythrocyte deformability, whole blood and plasma viscosity and hematological parameters were determined. Erythrocyte deformability significantly worsened in arterial samples after hypertension and hypotension, and in sinus samples it was impaired after hypotension period. Hematocrit significantly increased in arterial and sinus samples during hypertensive period, accompanied by similar alterations in whole blood viscosity. We conclude that hemodynamic changes caused by hyperventilation, hyper- or hypotension can influence hemorheological factors, and suggest that the rheological alterations can affect local hemodynamic and metabolic conditions.
