Effect of chinoin – 123, a pyrido (1,2-a) pyrimidine derivative on blood rheology in diabetic patients with peripheral occlusive angiopathy

Article type: Research Article

Authors: Lipovac, V. | Gavella, M. | Coce, F.

Affiliations: Vuk Vrhovac Institute for Diabetes, Endocrinology and Metabolic Diseases, Faculty of Medicine, University of Zagreb, Dugi dol 4a, 41000 Zagreb, Yugoslavia

Note: [] Accepted by: Editor M.R. Boisseau

Abstract: A double-blind trial was conducted among 41 diabetics with peripheral occlusive angiopathy to evaluate the effectiveness of Chinoin on blood rheology abnormalities. A significant improvement in whole blood filterability was obtained in a hypercholesterolaemic subgroup of these patients following 6 months of Chinoin treatment. These changes were probably due to the drug induced reduction in serum cholesterol and protein levels. The leucocyte counts in this subgroup did not undergo significant changes. The results obtained indicate that Chinoin may at least in part reduce blood rheology abnormalities in vasculopathy of diabetics.

Keywords: Diabetes, Erythrocyte filterability, Chinoin, Occlusive angiopathy

DOI: 10.3233/CH-1989-9607

Journal: Clinical Hemorheology and Microcirculation, vol. 9, no. 6, pp. 965-972, 1989