In vitro and in vivo study of the role of red blood cell aggregation in capillary flow pharmacology applications

Issue title: Red Cell Aggregation. Proceedings of the Second International Symposium. Paris, France, January 1988

Guest editors: J.F. Stoltz

Article type: Research Article

Authors: Dufaux, J. | Durussel, J.J. | Othmane, A.

Affiliations: L.B.H.P., Université Paris VII, 2, Place Jussieu, 75251 Paris Cedex 05, France

Note: [] Accepted by: Editor J.F. Stoltz

Abstract: RBCs aggregation plays a very important role at the microcirculatory level. In order to have a better understanding of the different parameters involved, we first presented results obtained in glass capillaries. The existence of a plasmatic layer and of a yield shear stress and the effect on the viscosity of RBCs suspensions has been proved. We then after presented results obtained on rats when the RBCs aggregation level was modified. The increase of the hydraulic resistance, important modifications of the systemic blood pressure, of the cardiac frequency and of the electrocardiogram were observed. Effect of troxerutine were studied.

Keywords: RBC’s Aggregation, Microcirculation, Cardiac disorders

DOI: 10.3233/CH-1989-9510

Journal: Clinical Hemorheology and Microcirculation, vol. 9, no. 5, pp. 797-807, 1989