Influence of plasma proteins on erythrocyte aggregation

Issue title: Red Cell Aggregation. Proceedings of the Second International Symposium. Paris, France, January 1988

Guest editors: J.F. Stoltz

Article type: Research Article

Authors: Donner, M.^a | Mills, P.^b | Stoltz, J.F.^a

Affiliations: [a] INSERM U 284, C0.10, Plateau de Brabois, 54511 Vandoeuvre Les Nancy, Cedex, France | [b] LBHP, Université Paris VII, 2 place Jussieu, 75251 Paris, Cedex 05, France

Note: [] Accepted by: Editor-in-Chief A.L. Copley

Abstract: This paper deals with the effect of albumin and immunoglobulins on erythrocyte aggregation parameters. The study was carried out with an automatic system based on the light reflectometry technique which allows to determine kinetic parameters and dissociation shear rates. The plasma substitution by physiological solution or albumin showed the role of albumin on dissociation shear rates. Albumin properties were altered by heating at 56–60°C. In presence of immunoglobulins, the role of albumin appeared to be complex, depending on the Alb/Glo ratio.

Keywords: Erythrocyte aggregation, Albumin, Immunoglobulins

DOI: 10.3233/CH-1989-9503

Journal: Clinical Hemorheology and Microcirculation, vol. 9, no. 5, pp. 715-721, 1989