Affiliations: [a] Laboratoire de Pharmacologie, Université René Descartes, Paris V, 4, avenue de l’Observatoire, F. 75270 Paris, Cedex 06 | [b] Laboratoire de Pharmacologie, Université de Lille II, F. 59000 Lille, France
Note: [] Accepted by: Editor M.R. Boisseau (Received in final form by Executive Editorial Office 10.1.1989)
Abstract: Experiments were realized on conscious Wistar rats with preoccluded both vertebral and right carotid arteries. Thrombus formation was induced in the left carotid artery by applying an anodal current of 1 mA during 12 minutes. Following the left carotid obstruction by the thrombus, rats became unresponsive and lost their righting reflex. The ability of various compounds to delay the loss of the righting reflex was investigated. Heparin, prostacyclin, iloprost, the thromboxane receptor antagonist BM 13177 and naftidrofuryl exerted a significant activity, whereas acetylsalicylic acid, dipyridamole, sulfinpyrazone, and the thromboxane synthetase inhibitor, dazmegrel, were inefficient
