Leukotriene C₄ decreases red blood cell deformabillty, as assessed by increased filtration index

Article type: Research Article

Authors: Mary, A. | Modat, G. | Gal, L. | Bonne, C.^{; *}

Affiliations: Laboratoire de Physiologie Cellulaire, Université Montpellier I, 15 ave Charles Flahault, 34060 Montpellier cedex, France

Correspondence: [*] Correspondence to: C. Bonne.

Note: [] Accepted by: Editor M.R. Boisseau

Abstract: The functional involvement of the previously characterized high affinity binding of leukotriene C4 (LTC4) in human red blood cells (RBC) has been investigated. By using a filtration technique in vitro, it was demonstrated that LTC4 reduced erythrocyte deformability at low concentrations (10 −10 - 10−6 mol. I−1). This effect is highly specific since LTD4 did not decrease the filterability of the cells. Factors affecting the binding also modified the filtration index. The possible role of this leucocyte metabolite in hemorheological disturbances including RBC deformability is suggested.

Keywords: Leukotriene C₄, erythrocyte deformability, erythrocyte filterability, inflammation, glutathione

DOI: 10.3233/CH-1989-9204

Journal: Clinical Hemorheology and Microcirculation, vol. 9, no. 2, pp. 209-217, 1989