Erythrocyte filterability in patients with cerebrovascular insufficiency. Effect of pentoxifylline and dipyridamole. Preliminary results

Article type: Research Article

Authors: Vaya, A. | Aznar, J. | Villa, P. | Valles, J. | Santos, M.T. | Martinez-Sales, V.

Affiliations: Department of Clinical Pathology and Research Center, Hospital “La Fe”, Valencia, Spain

Note: [] Accepted by: Editor M.R. Boisseau

Abstract: The present study evaluates the whole blood filterability index (WB-FI) and the washed red blood cell filterability index (WRBC-FI) in 21 chronic cerebrovascular insufficiency (CCVI) patients and in 36 control subjects. Althoug no significant differences were found in the mean values of the two groups, approximately 30% of the patients had a decreased WB-FI. Of the 7 CCVI patients who showed reduced WB-FI, this decrease could be attributed to erythrocyte deficiency in only two of the cases. Of the 21 CCVI patients, pentoxifylline (POX) was administered to 9, dipyridamole (DIP) to 6 and POX+DIP to another 6. The changes in WB-FI were evaluated 7, 15 and 45 days after treatment was begun. POX and DIP administered separately favoured WB-FI at 15 and 7 days respectively, but when administered together, WB-FI only increased slightly on the 45th day.

Keywords: erythrocyte filterability, cerebrovascular insufficiency, pentoxifylline, dipyridamol

DOI: 10.3233/CH-1988-8523

Journal: Clinical Hemorheology and Microcirculation, vol. 8, no. 5, pp. 773-778, 1988